InterPro domain: IPR039127

Trm112 is a component of several multifunctional methyltransferases. When associated with methyltransferase Mtq2, the enzyme methylates 'Gln-182' of eRF1. Mtq2 is the catalytic subunit, and Trm112 is required for its solubility and activity [ 1 ]. When associated with methyltransferase Trm11, the enzyme forms 2-methylguanosine at position 10 (m2G10) in tRNA [ 2 ]. When associated with methyltransferase Bud23, the enzyme forms 7-methylguanine at position 1575 (m7G1575) in 18S rRNA [ 3 , 4 ].

1. The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast. J. Biol. Chem. 281, 36140-8
2. Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. Mol. Cell. Biol. 25, 4359-70
3. The methyltransferase adaptor protein Trm112 is involved in biogenesis of both ribosomal subunits. Mol. Biol. Cell 23, 4313-22
4. Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575. Mol. Cell. Biol. 32, 2254-67