InterPro domain: IPR039119

This entry represents the nuclear protein ABT1 and its homologous counterpart, pre-rRNA-processing protein Esf2 (eighteen S factor 2), from yeast.

ABT1 associates with the TATA-binding protein (TBP) and enhances basal transcription activity of class II promoters. Meanwhile, ABT1 could be a transcription cofactor that can bind to DNA in a sequence-independent manner [ 1 ].

Esf2 is involved in pre-18S rRNA processing and is required for SSU processome assembly and function [ 2 ]. It binds to RNA and stimulates ATPase activity of Dbp8 [ 3 ].

1. A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth. Mol. Cell. Biol. 20, 1407-18
2. Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Mol. Cell. Biol. 25, 5523-34
3. The nucleolar protein Esf2 interacts directly with the DExD/H box RNA helicase, Dbp8, to stimulate ATP hydrolysis. Nucleic Acids Res. 34, 3189-99