InterPro domain: IPR039113
General Information
- Identifier IPR039113
- Description Autophagy-related protein 29
- Number of genes 1
- Gene duplication stats Loading...
- Associated GO terms GO:0000045
Abstract
Autophagy-related (Atg) proteins play a role in autophagy. Atg29 forms a complex with Atg17 and Atg31. When autophagy is initiated, the Atg17-Atg31-Atg29 complex is first targeted to the phagophore assembly site (PAS) and then recruits other Atg proteins [ 1 ]. The complex is recruited to the PAS by Atg11. Atg29 contains an N-terminal functional domain, whereas the C terminus plays a regulatory role. Phosphorylation of the C-terminal domain of Atg29 is required for its interaction with Atg11 and proper PAS localization [ 2 ].
1. Organization of the pre-autophagosomal structure responsible for autophagosome formation. Mol. Biol. Cell 19, 2039-50
2. Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation. Proc. Natl. Acad. Sci. U.S.A. 110, E2875-84