InterPro domain: IPR039104

6-Phosphogluconolactonase ( 3.1.1.31 ) hydrolyses 6-phosphogluconolactone to 6-phosphogluconate. It is a component of the pentose phosphate pathway, required for the synthesis of D-ribulose 5-phosphate from D-glucose 6-phosphate [ 1 ]. The yeast Saccharomyces cerevisiae possesses four homologues, but 6-phosphogluconolactonase-like proteins 1 and 2 lack 6-phosphogluconolactonase activity [ 2 ].

1. Identification of the cDNA encoding human 6-phosphogluconolactonase, the enzyme catalyzing the second step of the pentose phosphate pathway(1). FEBS Lett. 459, 223-6
2. Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism. Genetics 168, 117-27