InterPro domain: IPR038959
General Information
- Identifier IPR038959
- Description Pre-mRNA-processing factor 19
- Number of genes 201
- Gene duplication stats Loading...
- Associated GO terms GO:0006281 GO:0061630 GO:0000974 GO:0000398
Abstract
This family includes Pre-mRNA-processing factor 19 (Prp19) and its homologues. Prp19 is an ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR) [ 1 ]. Human Prp19 is part of the nineteen complex (NTC), which acts as a multimeric E3 ubiquitin ligase in DNA repair and splicing. Prp19 forms a homotetramer and is an autoinhibited E3 ubiquitin ligase; its activation requires its interaction with splicing factors SPF27, CDC5L, and PLRG1 [ 2 ].
1. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Mol. Cell 53, 235-46
2. Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors. Mol. Cell 69, 979-992.e6