InterPro domain: IPR038887

General Information

  • Identifier IPR038887
  • Description Dehydrodolichyl diphosphate synthase complex subunit Nus1
  • Number of genes 149
  • Gene duplication stats Loading...
  • Associated GO terms GO:0019408   GO:1904423  

Abstract

Nus1 (also known as Nogo-B receptor, NgBR) is a subunit of cis-prenyltransferase, a enzymatic activity critical for the synthesis of dolichol, an obligate carrier of oligosaccharides for protein glycosylation reactions [ 1 ]. It plays an essential role in angiogenesis during wound healing and embryonic development. In mice, it is essential for endothelial cell glycosylation and vascular development [ 2 ]. In zebrafish, it is bound by Nogo-B ligand that activates Akt pathway to stimulate endothelial cell chemotaxis [ 3 ]. In humans, it is involved in breast cancer cell growth through modulating Ras signaling [ 4 ].


1. Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab. 20, 448-57
2. NgBR is essential for endothelial cell glycosylation and vascular development. EMBO Rep. 17, 167-77
3. Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway. Blood 116, 5423-33
4. SAXS analysis of a soluble cytosolic NgBR construct including extracellular and transmembrane domains. PLoS ONE 13, e0191371

Species distribution

Gene table

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