InterPro domain: IPR038887
General Information
- Identifier IPR038887
- Description Dehydrodolichyl diphosphate synthase complex subunit Nus1
- Number of genes 149
- Gene duplication stats Loading...
- Associated GO terms GO:0019408 GO:1904423
Abstract
Nus1 (also known as Nogo-B receptor, NgBR) is a subunit of cis-prenyltransferase, a enzymatic activity critical for the synthesis of dolichol, an obligate carrier of oligosaccharides for protein glycosylation reactions [ 1 ]. It plays an essential role in angiogenesis during wound healing and embryonic development. In mice, it is essential for endothelial cell glycosylation and vascular development [ 2 ]. In zebrafish, it is bound by Nogo-B ligand that activates Akt pathway to stimulate endothelial cell chemotaxis [ 3 ]. In humans, it is involved in breast cancer cell growth through modulating Ras signaling [ 4 ].
1. Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab. 20, 448-57
2. NgBR is essential for endothelial cell glycosylation and vascular development. EMBO Rep. 17, 167-77
3. Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway. Blood 116, 5423-33
4. SAXS analysis of a soluble cytosolic NgBR construct including extracellular and transmembrane domains. PLoS ONE 13, e0191371