InterPro domain: IPR038804

This entry includes the plant root meristem growth factors 1 /2/3 (RGF1/2/3, also known as GOLVEN 11/5/7) from Arabidopsis. They are signaling peptide that maintains the postembryonic root stem cell niche in a PIN2-traffic dependent manner [ 1 , 2 , 3 ]. RGF1 (At5g60810) acts as a peptide hormone recognized by receptors such as RGI1 and RGI2 to trigger signaling events including the regulation of RITF1 expression and leading to the production of reactive oxygen species (ROS) in roots to modulate meristem size [ 4 ].

1. Secreted peptide signals required for maintenance of root stem cell niche in Arabidopsis. Science 329, 1065-7
2. Transcriptional and functional classification of the GOLVEN/ROOT GROWTH FACTOR/CLE-like signaling peptides reveals their role in lateral root and hair formation. Plant Physiol 161, 954-70
3. Distinct sensitivities to phosphate deprivation suggest that RGF peptides play disparate roles in Arabidopsis thaliana root development. New Phytol 207, 683-91
4. RGF1 controls root meristem size through ROS signalling. Nature 577, 85-88