InterPro domain: IPR038772

This entry includes SMPD2 from animals, Isc1/Css1 from yeasts and sphingomyelinase C (also known as sph) from bacteria.

Neutral sphingomyelinase (nSMase) sphingomyelin phosphodiesterase SMPD2 hydrolyzes sphingomyelin to phosphocholine and ceramide. SMPD2, differently to nSMase SMPD3, which is prominent in brain, is ubiquitously expressed [ 1 ]. Both are involved in vesicle budding from the plasma membrane [ 2 ].

Budding yeast Isc1 is inositol phosphosphingolipid phospholipase C that localizes to mitochondria in the post-diauxic phase of yeast growth [ 3 ]. Fission yeast Isc1 homologue, Css1, localizes to the entire plasma membrane and secretory pathway [ 4 ].

1. Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development. Proc. Natl. Acad. Sci. U.S.A. 102, 4554-9
2. Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane. J Extracell Vesicles 6, 1378056
3. ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae. J. Biol. Chem. 284, 10818-30
4. Coordination between fission yeast glucan formation and growth requires a sphingolipase activity. Genetics 158, 1397-411