InterPro domain: IPR038763

DHH phosphoesterase superfamily includes manganese-dependent inorganic pyrophosphatase (family II), Drosophila prune protein and bacterial RecJ exonuclease [ 1 ]. Typically, its members consist of two non-similar domains:domain 1 with parallel sheet of 6 strands and domain 2 with mixed sheet of 5 strands.

1. The crystal structure of exonuclease RecJ bound to Mn2+ ion suggests how its characteristic motifs are involved in exonuclease activity. Proc. Natl. Acad. Sci. U.S.A. 99, 5908-12