InterPro domain: IPR038753

General Information

  • Identifier IPR038753
  • Description NF-kappa-B inhibitor-like protein 1
  • Number of genes 11
  • Gene duplication stats Loading...
  • Associated GO terms GO:0007249  

Abstract

NF-kappa-B inhibitor-like protein 1 (NFKBIL1, also known as IKBL) is a member of the nuclear IkB family. Classical IkB proteins retain NF-kB dimers in the cytoplasm; IkBL belongs to the atypical or nuclear IkB proteins [ 1 ]. It inhibits LPS-induced NF-kB activation and transcription of TNF-alpha and IL-6 [ 2 ].


1. Atypical IκB proteins in immune cell differentiation and function. Immunol. Lett. 171, 26-35
2. IκBL, a novel member of the nuclear IκB family, inhibits inflammatory cytokine expression. FEBS Lett. 585, 3577-81

Species distribution

Gene table