InterPro domain: IPR038738

Nedd8 (also known as Rub1) has a single conserved ubiquitin-like domain that is part of a protein modification pathway similar to that of ubiquitin [ 1 ]. Nedd8 modifies a family of molecular scaffold proteins called cullins that are responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis [ 2 ]. This entry also includes Nedd8-like proteins from fungi and plants.

1. Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins. Semin. Cell Dev. Biol. 15, 221-9
2. Nedd8 on cullin: building an expressway to protein destruction. Oncogene 23, 1985-97