InterPro domain: IPR038738

General Information

  • Identifier IPR038738
  • Description Nedd8-like ubiquitin
  • Number of genes 168
  • Gene duplication stats Loading...

Abstract

Nedd8 (also known as Rub1) has a single conserved ubiquitin-like domain that is part of a protein modification pathway similar to that of ubiquitin [ 1 ]. Nedd8 modifies a family of molecular scaffold proteins called cullins that are responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis [ 2 ]. This entry also includes Nedd8-like proteins from fungi and plants.


1. Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins. Semin. Cell Dev. Biol. 15, 221-9
2. Nedd8 on cullin: building an expressway to protein destruction. Oncogene 23, 1985-97

Species distribution

Gene table

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