InterPro domain: IPR038738
General Information
- Identifier IPR038738
- Description Nedd8-like ubiquitin
- Number of genes 168
- Gene duplication stats Loading...
Abstract
Nedd8 (also known as Rub1) has a single conserved ubiquitin-like domain that is part of a protein modification pathway similar to that of ubiquitin [ 1 ]. Nedd8 modifies a family of molecular scaffold proteins called cullins that are responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis [ 2 ]. This entry also includes Nedd8-like proteins from fungi and plants.
1. Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins. Semin. Cell Dev. Biol. 15, 221-9
2. Nedd8 on cullin: building an expressway to protein destruction. Oncogene 23, 1985-97
Species distribution
Gene table
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