InterPro domain: IPR038736

This entry includes GDP-mannose transporter 1 (GMT1, also known as Vrg4) and related proteins mostly from fungi and plants. In budding yeasts, Vrg4 is involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen [ 1 ].

This entry also includes the nucleotide sugar transporter GONST1 from Arabidopsis. It is a golgi-localized GDP-mannose transporter [ 2 ].

1. The VRG4 gene is required for GDP-mannose transport into the lumen of the Golgi in the yeast, Saccharomyces cerevisiae. J. Biol. Chem. 272, 31908-14
2. Identification and characterization of GONST1, a golgi-localized GDP-mannose transporter in Arabidopsis. Plant Cell 13, 2283-95