InterPro domain: IPR038635

The Ccr4-Not complex controls mRNA metabolism at multiple levels in eukaryotic cells [ 1 , 2 ]. This complex is a major cytoplasmic deadenylase consisting of a combination of at least nine subunits, four of which have deadenylase activity [ 3 ]. The conserved core of the CCR4-NOT complex consists of two major modules: a catalytic module comprising two deadenylases (CAF1 or its paralogue POP2, and CCR4a or its paralogue CCR4b) and the NOT module, which minimally consists of NOT1, NOT2 and NOT3 [ 4 ].

This entry represents the C-terminal domain of NOT2, NOT3 and NOT5 (subunits 2, 3 and 5 of the complex). The C-terminal regions of NOT2 and NOT3 contain a conserved SH3-like NOT-box domain which mediates NOT-module assembly [ 5 ].

1. Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex. J. Biol. Chem. 279, 10848-54
2. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. Biochem. J. 398, 461-7
3. CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death. Genes Cells 16, 368-79
4. The Ccr4--not complex. Gene 492, 42-53
5. Structure and assembly of the NOT module of the human CCR4-NOT complex. Nat. Struct. Mol. Biol. 20, 1289-97