InterPro domain: IPR038608
General Information
- Identifier IPR038608
- Description Csm1/Pcs1, C-terminal domain superfamily
- Number of genes 1
- Gene duplication stats Loading...
Abstract
Saccharomyces cerevisiae Csm1 is part of the monopolin complex. Csm1 forms a complex with Mde4 and promotes monoorientation during meiosis [ 1 ]. It plays a mitotic role in DNA replication [ 2 ] and is required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation [ 2 ]. This entry also contains the Schizosaccharomyces pombe homologue to Csm1, Pcs1. Pcs1 forms a complex with Mde4 and acts in the central kinetochore domain to clamp microtubule binding sites together[ 3 ]. The two complexes (Csm1/Lrs4 and Pcs1/Mde4) contribute to the prevention of merotelic attachment [ 4 ].
1. Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex. Exp. Cell Res. 294, 592-602
2. The cis element and factors required for condensin recruitment to chromosomes. Mol. Cell 34, 26-35
3. The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation. Curr. Biol. 17, 1190-200