InterPro domain: IPR038607

Alkaline phosphatase D (PhoD) [ 1 ] catalyses the reaction: phosphate monoester + H(2)O = an alcohol + phosphate. PhoD is similar to Ca(2+)-dependent phospholipase D [ 2 ], which catalyses the hydrolysis of the ester bond between the phosphatidic acid and alcohol moieties of phospholipids [ 3 , 4 ].

1. A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD. Microbiology (Reading, Engl.) 142 ( Pt 8), 2041-7
2. Phosphate control of phoA, phoC and phoD gene expression in Streptomyces coelicolor reveals significant differences in binding of PhoP to their promoter regions. Microbiology (Reading, Engl.) 153, 3527-37
3. Expression and characterization of a heterodimer of Streptomyces chromofuscus phospholipase D. Biochim. Biophys. Acta 1703, 43-51
4. An iron-dependent bacterial phospholipase D reminiscent of purple acid phosphatases. J. Biol. Chem. 278, 13706-11