InterPro domain: IPR038595

The structure of protein LURP-one-related 15 (At5g01750) has been solved. It comprises a 12-stranded beta barrel with a central C-terminal alpha helix. This helix is thought to be a transmembrane helix. It is structurally similar to the C-terminal domain of the Tubby protein [ 1 ]. In plants LURP1 plays a role in defense against pathogens [ 2 ].

1. Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors. Bioinformatics 25, 159-62
2. The oomycete response gene LURP1 is required for defense against Hyaloperonospora parasitica in Arabidopsis thaliana. Plant J. 55, 53-64