InterPro domain: IPR038578
General Information
- Identifier IPR038578
- Description GT29-like superfamiliy
- Number of genes 450
- Gene duplication stats Loading...
Abstract
Glycosyltransferase family 29 ( GT29 ) comprises enzymes with a number of known activities; sialyltransferase ( 2.4.99 ), beta-galactosamide alpha-2,6-sialyltransferase ( 2.4.99.1 ), alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase ( 2.4.99.3 ), beta-galactoside alpha-2,3-sialyltransferase ( 2.4.99.4 ), N-acetyllactosaminide alpha-2,3-sialyltransferase ( 2.4.99.6 ), alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase ( 2.4.99.8 ); lactosylceramide alpha-2,3-sialyltransferase ( 2.4.99.9 ). These enzymes use a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar.
Sialyltransferase may be responsible for the synthesis of the sequence NEUAC-Alpha-2,3-GAL-Beta-1,3-GALNAC-, found on sugar chains O-linked to thr or ser and also as a terminal sequenec on certain gagnliosides. These enzymes catalyse sialyltransfer reactions during glycosylation, and are type II membrane proteins.