InterPro domain: IPR038528

This entry represents a conserved domain found in a group of proteins called telomere-length regulation TEL2, or clock abnormal protein-2, which are conserved from plants to humans. These proteins regulate telomere length and contribute to silencing of sub-telomeric regions [ 1 ]. In vitro the protein binds to telomeric DNA repeats.

Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling [ 2 ]. The structure of Tel2 consists of HEAT-like helical repeats that assemble into two separate alpha-solenoids [ 3 ]. This entry represents the C-terminal solenoid which consists of eleven helices.

1. The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Development 128, 4045-55
2. Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break. Genes Dev. 22, 854-9
3. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 24, 2019-30