InterPro domain: IPR038518

Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. More than 100 different families of glycoside hydrolases have been defined based on sequence similarity.

This entry represents the N-terminal beta sandwich domain found in glycosyl hydrolase family 63 proteins [ 1 ]. Glycosyl hydrolase family 63 is a family of eukaryotic enzymes that catalyse the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2).

1. Specificity of Processing α-glucosidase I is guided by the substrate conformation: crystallographic and in silico studies. J. Biol. Chem. 288, 13563-74