InterPro domain: IPR038511

The TOR signalling pathway activates a cell-growth program in response to nutrients [ 1 ]. TIP41 interacts with TAP42 and negatively regulates the TOR signalling pathway [ 2 ]. TAP42 is found in yeast and mammals, its homologue in plants is TAP46 [ 3 ]. TAP46 plays an essential role in plant growth and development as a component of the TOR signalling pathway [ 4 ].

1. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402, 689-92
2. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Mol. Cell 8, 1017-26
3. The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants. Plant Cell 23, 185-209