InterPro domain: IPR038324

General Information

  • Identifier IPR038324
  • Description Rpb4/RPC9 superfamily
  • Number of genes 443
  • Gene duplication stats Loading...

Abstract

A major role in the regulation of eukaryotic protein-coding genes is played by the gene-specific transcriptional regulators, which recruit the RNA polymerase II holoenzyme to the specific promoter. The Rpb4 and Rpb7 subunits of yeast RNA polymerase II form a heterodimeric complex essential for promoter-directed transcription initiation. The Rpb4-Rpb7 complex is not required for stable recruitment of polymerase to active preinitiation complexes, suggesting that Rpb4-Rpb7 mediates an essential step subsequent to promoter binding [ 1 ].

This superfamily includes DNA-directed RNA polymerase II subunit Rpb4 and DNA-directed RNA polymerase III subunit RPC9.


1. Dissociable Rpb4-Rpb7 subassembly of rna polymerase II binds to single-strand nucleic acid and mediates a post-recruitment step in transcription initiation. J. Biol. Chem. 276, 10097-102

Species distribution

Gene table

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