InterPro domain: IPR038273
General Information
- Identifier IPR038273
- Description Ndc80 domain superfamily
- Number of genes 144
- Gene duplication stats Loading...
Abstract
This entry represents a domain found in the kinetochore protein Ndc80. Ndc80 acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. It has been shown that Ndc80 from yeast is part of a complex called the Ndc80p complex [ 1 ]. The four Ndc80 complex subunits associate as two rod-like heterodimers (Ndc80:Nuf2 and Spc24:Spc25) [ 2 ]. This complex is thought to bind to the microtubules of the spindle.
1. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J. Cell Biol. 152, 349-60
2. Conserved Tetramer Junction in the Kinetochore Ndc80 Complex. Cell Rep 17, 1915-1922