InterPro domain: IPR038260

This superfamily represents the C-terminal domain of vacuolar protein sorting-associated protein 53 (Vps53), which is part of the of the GARP (Golgi-associated retrograde protein) complex involved in retrograde transport from early and late endosomes to late Golgi [ 1 , 2 , 3 ]. Budding yeast Vps53 is involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE Tgl1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles [ 4 ].

1. Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi. Mol. Biol. Cell 11, 305-23
2. Vps51p links the VFT complex to the SNARE Tlg1p. J. Biol. Chem. 277, 48318-24
3. Characterization of the human GARP (Golgi associated retrograde protein) complex. Exp. Cell Res. 306, 24-34