InterPro domain: IPR038222

This domain is called DHHA2 since it is often associated with the DHH domain and is diagnostic of DHH subfamily 2 members [ 1 ]. The domain is about 120 residues long and contains a conserved DXK motif at its amino terminus. It is present in inorganic pyrophosphatases and in exopolyphosphatase of Saccharomyces cerevisiae.

1. A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease. Trends Biochem. Sci. 23, 17-9