InterPro domain: IPR038192

General Information

  • Identifier IPR038192
  • Description Transcription termination and cleavage factor, C-terminal domain superfamily
  • Number of genes 273
  • Gene duplication stats Loading...

Abstract

The C-terminal section of cleavage stimulation and termination factor CstF-64 (CSTF2) and its yeast orthologue Rna15 form a discrete structure that is crucial for mRNA 3'-end processing [ 1 ]. This domain interacts with Pcf11 and possibly PC4, thus linking CSTF2 to transcription, transcriptional termination, and cell growth [ 2 ].


1. The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processing. J. Biol. Chem. 282, 2101-15
2. The hinge domain of the cleavage stimulation factor protein CstF-64 is essential for CstF-77 interaction, nuclear localization, and polyadenylation. J. Biol. Chem. 285, 695-704

Species distribution

Gene table