InterPro domain: IPR038167

This domain is found in structure-specific recognition protein SSRP1 (POB3 in yeast) and related proteins, which are components of the FACT complex - a general chromatin factor that acts to reorganise nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair [ 1 , 2 ]. During transcription elongation the FACT complex acts as a histone chaperone that both destabilises and restores nucleosomal structure [ 3 , 4 ].

This domain has a Pleckstrin homology fold, made of 6 beta strands.

1. The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo. Mol. Cell. Biol. 23, 8323-33
2. POB3 is required for both transcription and replication in the yeast Saccharomyces cerevisiae. Genetics 155, 1593-606
3. FACT, a factor that facilitates transcript elongation through nucleosomes. Cell 92, 105-16
4. FACT facilitates transcription-dependent nucleosome alteration. Science 301, 1090-3