InterPro domain: IPR038132

Vps16 forms part of the Class C vacuolar protein sorting (Vps) complex. It is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast [ 1 ]. The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole. It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport [ 2 ]. The role of VPS16 in this complex is not known.

The C-terminal domain of Vps16 binds to Vps33 for integration into the HOPS complex [ 3 , 4 ].

1. VACUOLELESS1 is an essential gene required for vacuole formation and morphogenesis in Arabidopsis. Dev. Cell 1, 303-10
2. The class C Vps complex functions at multiple stages of the vacuolar transport pathway. Traffic 2, 476-86
3. Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*. PLoS ONE 8, e67409
4. Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes. Traffic 16, 727-42