InterPro domain: IPR038120

RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This entry represents the funnel domain. The funnel domain contains the binding site for some elongation factors [ 1 , 2 ].

1. Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase. J. Biol. Chem. 271, 27969-74
2. Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Science 292, 1863-76