InterPro domain: IPR038107
General Information
- Identifier IPR038107
- Description 3-deoxy-D-manno-octulosonic-acid transferase, N-terminal domain superfamily
- Number of genes 111
- Gene duplication stats Loading...
Abstract
3-deoxy-D-manno-octulosonic-acid transferase (WaaA, KdtA) is involved in lipopolysaccharide biosynthesis. It catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the precursor of lipid A [ 1 ]. WaaA consists of two Rossmann-like domains. This superfamily represents the N-terminal domain, which is the acceptor-substrate binding domain. Structurally, it consists of 7 alpha helices and 5 beta strands [ 2 ].
1. Comparative analyses of secondary gene products of 3-deoxy-D-manno-oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia coli K-12. Eur. J. Biochem. 267, 5458-65
2. Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis. Proc. Natl. Acad. Sci. U.S.A. 109, 6253-8