InterPro domain: IPR038077

The troponin (Tn) complex regulates Ca ²⁺ induced muscle contraction. Tn contains three subunits, Ca ²⁺ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). This entry includes domains from troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin [ 1 , 2 , 3 ]. Structurally this domain forms a heterodimeric coiled coil.

1. Structure of co-crystals of tropomyosin and troponin. Nature 325, 826-8
2. A direct regulatory role for troponin T and a dual role for troponin C in the Ca2+ regulation of muscle contraction. J. Biol. Chem. 270, 2557-62
3. The troponin complex and regulation of muscle contraction. FASEB J. 9, 755-67