InterPro domain: IPR038019

General Information

  • Identifier IPR038019
  • Description Phosphoribosyl-AMP cyclohydrolase domain superfamily
  • Number of genes 152
  • Gene duplication stats Loading...

Abstract

The phosphoribosyl-AMP cyclohydrolase 3.5.4.19 catalyses the third step in the histidine (his) biosynthetic pathway:

5-phosphoribosyl-AMP H 2 O = 5-(5-phospho-D-ribosylaminoformimino)-1-(5-phospho-ribosyl) imidazole-4-carboxamide

It requires Zn 2 ions for activity [ 1 ].

Methanobacterium phosphoribosyl-AMP cyclohydrolase HisI is a dimer; each monomer is composed of four beta-hairpins [ 2 ].


1. N1-(5'-phosphoribosyl)adenosine-5'-monophosphate cyclohydrolase: purification and characterization of a unique metalloenzyme. Biochemistry 38, 1537-46
2. Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI. Biochemistry 44, 10071-80

Species distribution

Gene table