InterPro domain: IPR037867

The COMPASS (Complex Proteins Associated with Set1 or Set1C) is the yeast homologue of the human MLL complex, which is required for mono-, di-, and trimethylation of lysine 4 of histone H3 [ 1 ]. It is required in telomeric transcriptional silencing [ 2 ]. The complex consists of Set1, Bre2, Spp1, Sdc1, Shg1, Swd1, Swd2, and Swd3 [ 3 , 4 ].

This entry includes Swd2 from yeasts and WDR82 from animals. They are part of the Set1/COMPASS complex [ 5 ].

Besides being part of the Set1/COMPASS complex, Swd2 is also a component of the cleavage and polyadenylation factor (CPF) complex and its subcomplex APT [ 6 , 7 , 8 ].

1. Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. Mol. Cell 24, 2932-43
2. COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J. Biol. Chem. 277, 10753-5
3. The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J. 20, 7137-48
4. COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc. Natl. Acad. Sci. U.S.A. 98, 12902-7
5. Molecular regulation of H3K4 trimethylation by Wdr82, a component of the human Set1/COMPASS. Mol. Cell. Biol. 278, 33000-10
6. Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J. Biol. Chem. 8, 2421-36
7. The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol. Cell. Biol. 287, 15219-31
8. Yeast Swd2 is essential because of antagonism between Set1 histone methyltransferase complex and APT (associated with Pta1) termination factor. J. Biol. Chem.