InterPro domain: IPR037850

This entry includes RBBP5 from animals, RBL from plants and Swd1 from yeasts.

Swd1 is a component of the SET1C/COMPASS complex, a complex that methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres [ 1 , 2 ].

Retinoblastoma-binding protein 5 (RBBP5) is important for development in embryonic stem cells, regulating gene induction and H3 'Lys-4' methylation at key developmental loci [ 3 ]. It is a component of the SET1 histone methyltransferase complex [ 4 ], and methyltransferase-containing (COMPASS) complexes MLL1, MLL2/3 and MLL4 [ 5 , 6 ].

Arabidopsis RBL is also a component of a COMPASS-like complex that mediates histone H3 lysine-4 trimethylation to control floral transition and plant development [ 7 ].

1. The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J. 20, 7137-48
2. COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J. Biol. Chem. 277, 10753-5
3. Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell 284, 24242-56
4. Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription. EMBO J. 144, 513-25
5. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J. Biol. Chem. 31, 4310-8
6. The COMPASS family of H3K4 methylases in Drosophila. Mol. Cell. Biol.
7. Arabidopsis COMPASS-like complexes mediate histone H3 lysine-4 trimethylation to control floral transition and plant development. PLoS Genet. 282, 13419-28