InterPro domain: IPR037730

This entry represents the mitochondrial inner membrane protease (IMP) subunit 2 (MEROPS identifier S26.012). IMP removes an N-terminal targeting signal from a protein synthesized in the mitochondrial matrix but destined for export across the membrane to the mitochondrial inter-membrane space. IMP is a hetero-oligomer containing two homologous subunits that are both serine endopeptidases (IMP1 and IMP2) plus SOM1 [ 1 ]. IMP1 and IMP2 have overlapping specificities [ 2 ].

1. Purified inner membrane protease I of yeast mitochondria is a heterodimer. J. Biol. Chem. 269, 8635-8
2. The mitochondrial IMP peptidase of yeast: functional analysis of domains and identification of Gut2 as a new natural substrate. Mol. Genet. Genomics 271, 616-26