InterPro domain: IPR037706

General Information

  • Identifier IPR037706
  • Description DNA-dependent protein kinase catalytic subunit, catalytic domain
  • Number of genes 6
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004677   GO:0006281  

Abstract

This entry represents the catalytic domain of DNA-dependent protein kinase catalytic subunit (DNA-PKcs). The DNA-PK complex is composed of DNA-PKcs, the heterodimer Ku70/80, XRCC4, and ligase IV. The DNA-PK complex is involved in non-homologous end joining (NHEJ), a process of repairing double strand breaks (DSBs) by joining together two free DNA ends of little homology [ 1 ].


1. DNA-PKcs function regulated specifically by protein phosphatase 5. Proc. Natl. Acad. Sci. U.S.A. 101, 1247-52

Species distribution

Gene table