InterPro domain: IPR037692

CEP70 localizes to the centrosome throughout the cell cycle and binds to the key centrosomal component, gamma-tubulin [ 1 ]. It plays an important role in the regulation of microtubule dynamics, mitotic spindle formation, cell migration, and ciliogenesis [ 2 ]. It has been shown to regulate cancer growth and metastasis [ 3 , 4 ].

1. CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly. J. Biol. Chem. 286, 33401-8
2. Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization. Sci Rep 6
3. Centrosomal Protein 70 Is a Mediator of Paclitaxel Sensitivity. Int J Mol Sci 18, 21263