InterPro domain: IPR037675

General Information

  • Identifier IPR037675
  • Description GPI ethanolamine phosphate transferase 3, N-terminal
  • Number of genes 108
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006506   GO:0051377  

Abstract

GPI ethanolamine phosphate transferase 3 (also known as PIG-O) is an ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C terminus of the proteins by an amide bond [ 1 ].


1. Phenotype-genotype correlations of PIGO deficiency with variable phenotypes from infantile lethality to mild learning difficulties. Hum. Mutat. 38, 805-815

Species distribution

Gene table