InterPro domain: IPR037624
General Information
- Identifier IPR037624
- Description Nuclear pore complex protein Nup133-like
- Number of genes 127
- Gene duplication stats Loading...
- Associated GO terms GO:0017056
Abstract
This entry includes the nuclear pore complex proteins Nup133, Nup132, Nup131 and Nup15 (from Caenorhabditis elegans). Nup133 is a component of the Nup160 subcomplex, which consists of Nup160, Nup133, Nup107 and Nup96, and is important for mRNA export from the nucleus [ 1 ]. Nup160 subcomplexes are localized to both sides of the NPC during interphase. Nup133 also localizes to kinetochores [ 2 ]. Nup131 and Nup132 are components of the npc107-120 complex in Schizosaccharomyces pombe. This complex consists of nup85, nup107, nup120, nup131, nup132 and seh1 and is also required for mRNA export [ 3 ].
1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. J. Cell Biol. 155, 339-54
2. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J. Cell Biol. 154, 1147-60
3. The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division. Mol. Cell. Biol. 24, 6379-92