InterPro domain: IPR037607

Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. Upon cell stimulation, diacylglycerol kinase (DGK) converts DAG into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity [ 1 , 2 ]. Most vertebrate species contain 10 different DGK isozymes. The catalytic domain constitutes the single largest sequence element within the DGK proteins that is commonly and uniquely shared by all family members [ 3 ]. DGK proteins can be classified into five classes based on the presence or absence of specific functional domains. DGKs play an important role in controlling diverse cellular processes including development, cell division and proliferation, neuronal and immune responses, vascular traffic, apoptosis and cytoskeletal reorganization [ 3 ].

1. Molecules in focus: diacylglycerol kinase. PLoS ONE 29, 1139-43
2. Diacylglycerol kinases as emerging potential drug targets for a variety of diseases. Int. J. Biochem. Cell Biol. 9, 626-40
3. Phylogenetic analysis of the diacylglycerol kinase family of proteins and identification of multiple highly-specific conserved inserts and deletions within the catalytic domain that are distinctive characteristics of different classes of DGK homologs. null 12, e0182758