InterPro domain: IPR037597

Seh1 is a subunit of the Nup84 (Nup107-160 complex in higher eukaryotes) nuclear pore subcomplex [ 1 ] and the the SEA complex (GATOR1 complex in higher eukaryotes) [ 2 , 3 , 4 ].

The Nup107-160 complex, which is the major structural subcomplex of the nuclear pore complex (NPC), functions in the regulation of mRNA export as well as in the assembly and distribution of NPCs within the nuclear envelope, and may also have functions independent of nucleocytoplasmic transport [ 5 ].

In budding yeasts, the SEA complex associates with the vacuole and is involved in intracellular trafficking, amino acid biogenesis, and response to nitrogen starvation [ 6 ]. In Drosophila, GATOR1 complex inhibits TORC1 activity in response to amino acid limitation and contributes to multiple aspects of the development [ 6 ].

Both Sec13 and Seh1 are positive regulators of TORC1 signalling [ 6 ].

1. Structure and assembly of the Nup84p complex. J. Cell Biol. 149, 41-54
2. A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol. Cell Proteomics 10, M110.006478
3. The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in Drosophila melanogaster. G3 (Bethesda) 6, 3859-3867
4. SEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway. J. Cell. Sci. 128, 2219-28
5. The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis. Development 138, 2133-42
6. SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation. Cell Cycle 12, 2948-52