InterPro domain: IPR037464

Threonine aspartase 1 (taspase1) is a threonine aspartase and a member of the type 2 asparaginase family. It catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA [ 1 , 2 ]. The Taspase1 proenzyme undergoes autoproteolysis into alpha and beta subunits [ 3 ]. The N-terminal residue of the beta subunit is a threonine which is the active catalytic residue. The active enzyme is a heterotetramer [ 3 ].

1. Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell 115, 293-303
2. Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. Mol. Cell. Biol. 26, 2728-35
3. Crystal structure of human Taspase1, a crucial protease regulating the function of MLL. Structure 13, 1443-52