InterPro domain: IPR037445

The melanoma antigen (MAGE) protein family contains more than 25 members that share a conserved MAGE homology domain (MHD) [ 1 ].

Proteins known to contain a MAGE domain are listed below:

• Human MAGE-A, -B and -C proteins. MAGE-A, -B and -C genes are silent in all normal tissues with the exception of testis.
• Human MAGE-D to -L proteins. MAGE-D to -L genes are expressed in normal adult tissues.
• Mouse Mage-a and -b proteins.
• Mouse Mage-d, -e, -g, -h, -k and -l.
• Mammalian Necdin. The human Necdin gene is a candidate for the Prader-Willi syndrome.

1. An overview of the MAGE gene family with the identification of all human members of the family. Cancer Res. 61, 5544-51