InterPro domain: IPR037379
General Information
- Identifier IPR037379
- Description WDR74/Nsa1
- Number of genes 153
- Gene duplication stats Loading...
- Associated GO terms GO:0042273 GO:0005730
Abstract
Yeast Nsa1 is a ribosomal assembly factor that is functionally linked to type II AAA-ATPase Rix7. Rix7 associates with Nsa1-containing nucleolar pre-60S particles and is required for the maturation of the large ribosomal subunit. The mammalian homologue of Nsa1 is the nucleolar protein WDR74 (WD-repeat containing 74), which has been shown to associate with NVL2 (Rix7 homologue) in the presence of the nuclear Mtr4 exosome complex [ 1 ].
WDR74/Nsa1 is composed of an N-terminal seven-bladed WD40 domain followed by a lysine-rich C terminus that is required for nucleolar localization. The WD40 domain of WDR74 serves as a platform for recruitment of NVL2 to pre-60S particles [ 2 ].
1. AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74. Biochem. Biophys. Res. Commun. 467, 534-40
2. Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2. Structure 25, 762-772.e4