InterPro domain: IPR037360

COMM9 is a member of the COMMD family defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions [ 1 ]. COMM9 modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits [ 2 ].

1. COMMD proteins, a novel family of structural and functional homologs of MURR1. J. Biol. Chem. 280, 22222-32
2. Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel. Am. J. Physiol. Renal Physiol. 305, F80-9