InterPro domain: IPR037352

The WD40 domain-containing protein EED is the regulatory subunit of Polycomb repressive complex 2 (PRC2) [ 1 , 2 ], which mediates gene silencing primarily through methylation of lysine-27 of histone H3 [ 3 ]. The core subunits of the complex in mammals include EED, EZH2, SUZ12 and RBBP4. PRC2 is well conserved throughout evolution. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12 [ 4 , 5 ]. Drosophila has two copies of the Eed homologue, Esc and Esc-like [ 6 ].

1. Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED. PLoS ONE 12, e0169855
2. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 139, 1290-302
3. The Polycomb complex PRC2 and its mark in life. Nature 469, 343-9
4. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111, 185-96
5. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111, 197-208
6. ESC, ESCL and their roles in Polycomb Group mechanisms. Mech. Dev. 125, 527-41