InterPro domain: IPR037312
General Information
- Identifier IPR037312
- Description Protein kinase C-like, HR1 domain
- Number of genes 1
- Gene duplication stats Loading...
- Associated GO terms GO:0009272 GO:0004697
Abstract
This entry represents the second HR1 domain found in fungal PKC-like proteins including Pkc1p from Saccharomyces cerevisiae, and Pck1p and Pck2p from Schizosaccharomyces pombe. The yeast PKC-like proteins play a critical role in regulating cell wall biosynthesis and maintaining cell wall integrity [ 1 ]. They contain two HR1 domains, C2 and C1 domains, and a kinase domain. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family [ 2 ]. The HR1 domains of Pck1p and Pck2p interact with GTP-bound Rho1p and Rho2p [ 3 ].
1. Yeast protein kinase C. J. Biochem. 132, 513-7
2. The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1. Mol. Cell 4, 793-803
3. Regulation of yeast protein kinase C activity by interaction with the small GTPase Rho1p through its amino-terminal HR1 domain. Mol. Microbiol. 44, 829-40