InterPro domain: IPR037252

General Information

  • Identifier IPR037252
  • Description Mib/herc2 domain superfamily
  • Number of genes 12
  • Gene duplication stats Loading...
  • Associated GO terms GO:0004842   GO:0046872  

Abstract

Mib is a RING ubiquitin ligase in the Notch pathway. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalisation. Cell transplantation studies suggest that mib function is essential in the signalling cell for efficient activation of Notch in neighbouring cells. This domain has been named 'mib/herc2 domain' in [ 1 ] and usually the protein also contains an E3 ligase domain (either Ring or Hect).


1. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev. Cell 4, 67-82

Species distribution

Gene table

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