InterPro domain: IPR037239

A number of eukaryotic proteins that seem to be involved with sterol synthesis and/or its regulation have been found [ 1 ] to be evolutionary related. These include mammalian oxysterol-binding protein (OSBP), a protein of about 800 amino-acid residues that binds a variety of oxysterols (oxygenated derivatives of cholesterol); yeast OSH1, a protein of 859 residues that also plays a role in ergosterol synthesis; yeast proteins HES1 and KES1, highly related proteins of 434 residues that seem to play a role in ergosterol synthesis; and yeast hypothetical proteins YHR001w, YHR073w and YKR003w.

The core structure of OSBP has a large meander beta-sheet of 12 strands wrapped around the N-terminal (distorted) alpha-hairpin. It shares some similarity with transmembrane beta-barrel proteins.

1. A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Yeast 10, 341-53