InterPro domain: IPR037198

MutL and MutS are key components of the DNA repair machinery that corrects replication errors [ 1 ]. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signalling complex for repair. The N-terminal region of MutL contains the ATPase domain and the C-terminal is involved in dimerisation [ 2 ].

The structure of the C-terminal domain of MutL consists of two different alpha+beta (sub)domains, both composed of two layers (alpha/beta) with antiparallel sheet, where the second domain is inserted in the first one.

1. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem. 65, 101-33
2. Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. EMBO J. 23, 4134-45