InterPro domain: IPR036968
General Information
- Identifier IPR036968
- Description Enolpyruvate transferase domain superfamily
- Number of genes 256
- Gene duplication stats Loading...
- Associated GO terms GO:0016765
Abstract
5-enolpyruvylshikimate 3-phosphate synthase (EPSPS), also known as 3-phosphoshikimate 1-carboxyvinyltransferase, and UDP-N-acetylglucosamine enolpyruvyl transferase (MurA), also known as UDP-N-acetylglucosamine 1-carboxyvinyltransferase, have both a unique three-dimensional topology and overall reaction mechanism in common [ 1 ]. This entry represents the core domain superfamily of EPSPS and MurA, which transfers enolpryruvate from phosphoenolpyruvate to 3-phosphoshikimate and UDP-N-acetyl-alpha-D-glucosamine respectively.
1. Substrate and inhibitor-induced conformational changes in the structurally related enzymes UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate 3-phosphate synthase (EPSPS). Biochemistry 38, 8864-78